Fermentation pharmaceutical production lines are used to produce pharmaceutical products, such as antibiotics, vaccines, and enzymes, through fermentation processes. Fermentation is a biological process in which microorganisms, such as bacteria or fungi, are used to produce desired compounds.
Here are some key components and steps involved in a typical fermentation pharmaceutical production line:
Fermenter: The fermenter, also known as a bioreactor, is the main vessel where the fermentation process takes place. It provides an optimal environment for the growth of microorganisms, such as temperature, pH, and oxygen levels.
Inoculation: The production line starts with inoculating the fermenter with a selected strain of microorganism capable of producing the desired product.
Growth phase: The microorganisms are allowed to grow and reproduce in the fermenter, typically under controlled conditions. This phase may involve monitoring and controlling parameters like temperature, pH, and nutrient levels to ensure optimal growth.
Production phase: Once the microorganisms reach a certain density, the production phase begins. The microorganisms are induced to produce the desired pharmaceutical product, which may be a secondary metabolite or a recombinant protein.
Harvesting: After the production phase, the fermented broth containing the desired product is harvested from the fermenter. This can be done by separating the microorganisms from the broth using techniques like centrifugation or filtration.
Purification: The harvested broth undergoes various purification steps to isolate and concentrate the desired pharmaceutical product. These steps may include filtration, chromatography, and precipitation.
Formulation and packaging: Once the product is purified, it goes through formulation and packaging processes to prepare it for distribution and use. This may involve adding excipients, stabilizers, and preservatives, and packaging the final product into vials, syringes, or other appropriate containers.
Quality control: Throughout the production line, quality control measures are implemented to ensure that the final product meets the required specifications and is safe for use. This includes testing for purity, potency, sterility, and other quality parameters.
It's important to note that the specific details of a fermentation pharmaceutical production line may vary depending on the product being manufactured and the specific requirements of the process.
Biopharmaceutical Engineering Cases
Fully automatic probiotic fermentation system with an annual production capacity of 60 tons
Functional characteristics of a fully automatic probiotic fermentation system
1. Capable of achieving in situ automatic sterilization (SIP)
2. In situ automatic cleaning (CIP)
3. Fully automatic control of fermentation process (automatic measurement and measurement control of temperature, stirring speed, PH, DO feeding and aeration tank
pressure and liquid level, defoaming and weighing, etc.)
Service of fully automatic probiotic fermentation system
1. Beyond is responsible for process design, automation programming, equipment design and manufacturing, as well as public engineering supporting equipment modeling
and procurement services.
2. The entire project installation and automation integration.
3. A turnkey engineering project that integrates debugging and training.
Intelligence of fully automatic probiotic fermentation system
1. Fully automatic PLC+Wincc central integrated control
2. Equipped with powerful image display and data processing functions
3. Can handle real-time and historical data
4. Can switch between manual, automatic, and remote control modes
5. Ability to display trend curves for analyzing all data
6. Can store and display historical curves for analyzing all data
7. Batch number report that can display all parameters
8. Can directly copy data using USB drive
9. The data storage format is compatible with EXCEL and can be processed on the EXCEL platform
Main equipment of fully automatic probiotic fermentation system
1. 300L chemical tank, 500L alkali tank, 10T high-speed mixer, 5000L ingredient tank, 240L seed tank, 5000L fermentation tank
2. 3T ultra-high temperature instantaneous sterilization machine degasser
3. Protector tank, emulsification embedding tank
4. Composition of GEA butterfly centrifuge and Chutian freeze-drying machine
The fully automatic probiotic fermentation system realizes automatic feeding and discharging, all links can be automatically sterilized and CIP cleaned online,
all production process parameters can be recorded and traceable, supporting MIS system, and can achieve equipment performance management and quality management,
as well as energy management and production management, equipment operation and maintenance management, material management and other report forms,
providing program diagnosis or modification functions for authorized administrators of the factory, At the same time, BEYOND also provides technical services such as remote
diagnosis and modification.
